Nuno Basílio, researcher at NOVA and co-author of the work recently published in the Journal of the American Chemical Society ( JACS).Īccording to the authors, the synthesis of such molecular photoswitches shows their potential for the light-triggered delivery of large biomolecules and envisage new possibilities in remotely controlled systems for pharmaceutical applications. "The dynamic control of the structure and polarity of counterion activators by using light offers a promising conceptual strategy to develop stimuli responsive membrane carriers," explained Dr. When light irradiated, azobenzenes units change their configuration from a more polar to a more hydrophobic conformation, successfully making their way into the cytosol. Counterions are oppositely charged ions that are attracted to the charged compound, forming charge-neutralized complexes with higher membrane permeability in this case. Javier Montenegro, Principal Investigator at CiQUS. "Our design relied on calixarene-based receptors with an azobenzene unit that can be applied as photoresponsive counterion to gain control over the transport of cationic peptides," said Prof. ![]() Obtained from modern ultrastructural characterization methods.In collaboration with a team from the Universidade Nova de Lisboa (NOVA), researchers from the Center for Research in Biological Chemistry and Molecular Materials (CiQUS) at University of Santiago de Compostela reported new light-responsive membrane transporters for the translocation of peptide cargos inside living cells. Supports geometries in 2D and 3D including large and irregular cell geometries Symbolic representation framework for specifying reaction pathways, and SMART is based on the FEniCS finite element library, provides a Specification and numerical simulation of spatially-varying reaction-transport ![]() (SMART), a high-performance finite-element-based simulation package for model This work, we describe Spatial Modeling Algorithms for Reactions and Transport ![]() Non-linearities, strong coupling, stiffness, and potential instabilities. (PDEs) are notoriously difficult to solve because of their high dimensionality, Such systems of multi-dimensional partial differential equations Within the cell) and domains (e.g., the bulk cell volume and the interior of These reaction pathways include numerous chemical species that react acrossīoundaries or interfaces (e.g., the cell membrane and membranes of organelles Propagation and reaction of chemical substances in cell signaling pathways canīe represented by coupled nonlinear systems of reaction-transport equations. Biological cells respond to stimuli through sequences ofĬhemical reactions generally referred to as cell signaling pathways. These geometries are now compatible with predictive modeling ofĬellular function. Irregular geometries of intracellular subcompartments such as membrane-bound The 2023 Gordon Conference on Mechanisms of Membrane Transport will continue the tradition of providing a forum to discuss recent and emerging research on the structure, function and physiology of macromolecules responsible for membrane transport. ![]() Laughlin (1) and 18 other authors Download PDF Abstract: Recent advances in microscopy and 3D reconstruction methods have allowed forĬharacterization of cellular morphology in unprecedented detail, including the Download a PDF of the paper titled SMART: Spatial Modeling Algorithms for Reaction and Transport, by Justin G.
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